Sodium Hydroxide → HCID 131727308, compound

HRID 1727961Notes

Reaction equation

HRID 1727961 reaction equation
C(OC([N:6]1[C:33]2[C:28](=[CH:29][CH:30]=[C:31]([Cl:34])[CH:32]=2)[C:8]2([CH:13]([CH:14]3[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]3)[CH2:12][C:11](=[O:20])[NH:10][CH:9]2[C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[CH:22]=2)[C:7]1=[O:35])=O)C.[OH-].[Na+]>CO>[Cl:34][C:31]1[CH:32]=[C:33]2[NH:6][C:7](=[O:35])[C:8]3([CH:13]([CH:14]4[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]4)[CH2:12][C:11](=[O:20])[NH:10][CH:9]3[C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[CH:22]=3)[C:28]2=[CH:29][CH:30]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 90721757HCID 90721757, compound

Product 1

HCID 131727308HCID 131727308, compoundYield 29%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a manner similar to the method described in example 4d, racemic (2′S,3S,4′R)-6-chloro-2′-(3-chlorophenyl)-4′-cyclohexyl-2,3-dihydro-2,6′-dioxospiro[indole-3,3′-piperidine]-1-carboxylic acid ethyl ester (0.2 g, 0.39 mmol) was reacted with NaOH (28 mg, 0.70 mmol) in methanol to give racemic (2′S,3S,4′R)-6-chloro-2′-(3-chlorophenyl)-4′-cyclohexylspiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione as a white solid (Yield 0.05 g, 29%).

Sources & evidence

ORD record
ord-1e79b1fd832d4b0c8239cb147a4f00ba
Source dataset
uspto-grants-2009_02
Patent number
US07495007B2

Reaction notes

Loading…