Z-6-bromo-3-(3-chloro-benzylidene)-1,3-dihydro-indol-2-one → racemic (2'R,3R,4'S)-6-bromo-4'-(3-chlorophenyl)-2,3-dihydro-2'-(5-chloro-2-methylphenyl)-2,6'-dioxospiro[indole-3,3'-piperidine]

Participants

Reaction Steps

In a manner similar to the method described in example 157b, E/Z-6-bromo-3-(3-chloro-benzylidene)-2-oxo-2,3-dihydro-indole (0.4 g, 1.10 mmol) prepared in example 157a was reacted with 1-(5-chloro-2-methylphenyl)-3-trimethylsilyoxy-2-aza-1,3-butadiene prepared in example 160a, in toluene to give racemic (2′R,3R,4′S)-6-bromo-4′-(3-chlorophenyl)-2,3-dihydro-2′-(5-chloro-2-methylphenyl)-2,6′-dioxospiro[indole-3,3′-piperidine] as a white solid. (Yield 0.3 g, 51%).

Provenance & Evidence