HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl malonate → 6-Methoxyoxindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl malonate | HCID 7943 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-Chloro-3-nitroanisole | HCID 25140 | — |
| Catalyst | Iron | HCID 23925 | — |
| Product | 6-Methoxyoxindole | HCID 2793749 | 18.4% |
Reaction Steps
In a manner similar to the method described in example 167a, 1-chloro-4-methoxy-2-nitro-benzene (19 g, 0.1 mol) was reacted with dimethyl malonate (16 g, 0.2 mol), NaH and iron power to give 6-methoxy-1,3-dihydro-indol-2-one (3 g, 18%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07495007B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-c0c477c2c2964da6a27dd33023cb8694 |
| Source note | uspto-grants-2009_02 |