Sodium Hydroxide → HCID 76568043, compound

Participants

Reaction Steps

To a stirred solution of racemic (2′R,3R,4′S)-6-chloro-4′-(3-chlorophenyl)-2′-[2-methoxy-5-(2-trimethylsilanyl-ethynyl)-phenyl]spiro[3H-indole-3,3′-piperidine]-2,6′-dione (50 mg, 0.088 mmol) in MeOH (2 ml) was added 2N NaOH dropwise. The reaction was stirred for 30 min and extracted with EtOAc. The combined organic extract was dried and concentrated and was purified by flash chromatography, eluting with CH2Cl2, then EtOAc. Recrystallization gave the title compound as a white solid (13 mg, 13% yield). MS (H+), 491

Provenance & Evidence