HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorotrimethylsilane → Trimethylsilyl 2,2-difluoro-2-(fluorosulfonyl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | 2,2-Difluoro-2-(fluorosulfonyl)acetic acid | HCID 2737516 | — |
| Product | Trimethylsilyl 2,2-difluoro-2-(fluorosulfonyl)acetate | HCID 2778022 | 75.6% |
Reaction Steps
Under argon protection and at 0° C., trimethylsilyl chloride (11.5 g, 106 mmol) was added dropwise slowly into 2-(fluorosulphonyl)difluoroacetic acid (5 g, 28 mmol). Then the mixture was stirred over weekend at r.t. Then the solvent was removed to give 5.3 g crude product as a liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07495007B2 |
| Source dataset | uspto-grants-2009_02 |
| ORD ID | ord-d2a5c7688f504bd28da986a9cc16b74b |
| Source note | uspto-grants-2009_02 |