Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 6-Chloro-1,3-dihydroindol-2-one | HCID 736344 | — |
| Reactant | 5-chloro-2-isopropoxybenzaldehyde | HCID 5199615 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 86617595 | HCID 86617595 | 77.5% |
Reaction Steps
5-Chloro-2-isopropoxy-benzaldehyde (3 g, 15.1 mmol) and 6-chlorooxindole (2 g, 12.6 mmol) were mixed in anhydrous methanol (30 mL) at room temperature. Then pyrrolidine (1.07 g, 15.1 mmol) was added slowly. The reaction mixture was heated at 70° C. for 3 h. Then the mixture was cooled to room temperature and filtered. The precipitate was dried and collected to give E/Z-6-chloro-3-(5-chloro-2-isopropoxy-benzylidene)-1,3-dihydro-indol-2-one as a yellow solid (3.4 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07495007B2 |
|---|
| Source dataset | uspto-grants-2009_02 |
|---|
| ORD ID | ord-181d317332c14686ac4859351d4f54f5 |
|---|
| Source note | uspto-grants-2009_02 |
|---|
