Sodium Hydroxide → HCID 76567925, compound

Participants

Reaction Steps

Racemic (2′R,3R,4′S)-6-chloro-4′-(5-chloro-2-methoxycarbonylmethoxy-phenyl)-2′-isopropenylspiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione (80 mg, 0.164 mmol) was dissolved in THF (10 mL). Then aqueous solution (1 mL) of NaOH (20 mg) was added. The mixture was refluxed for 1 h. After cooled to room temperature, the solution was concentrated and acidified to “pH” 2-3. The mixture was extracted with ethyl acetate. The organic layer was separated, dried and concentrated. The crude product (50 mg) was purified by Prep-HPLC to give the title compound as a white solid (14 mg).

Provenance & Evidence