反应详情

温度

80 °C

A mixture of racemic (2′S,3S,4′R)-6-chloro-4′-[5-chloro-2-(2-methoxycarbonyl-2-methyl-propoxy)-phenyl]-2′-(5-fluoro-2-methylphenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione (300 mg), NaOH (80 mg), H2O (10 mL) and methanol (10 mL) was heated at 80° C. for 2 h. Then the mixture was concentrated. The remaining aqueous solution was acidified to “pH” 2 by concentrated aqueous HCl. The white precipitate was collected by filtration to give title compound (Yield: 250 mg).

1. concentrationThen the mixture was concentrated
2. filtrationThe white precipitate was collected by filtration