Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 6-Chloro-1,3-dihydroindol-2-one | HCID 736344 | — |
| Reactant | 5-Chloro-2-methylbenzaldehyde | HCID 12347565 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 86760830 | HCID 86760830 | 92.5% |
Reaction Steps
5-Chloro-2-methyl-benzaldehyde (4 g, 16 mmol) and 6-chlorooxindole (2.5 g, 16 mmol) were mixed in anhydrous methanol (20 mL). Then pyrrolidine (1.32 mL, 16 mmol) was added slowly at r.t. The mixture was heated to 70° C. for 3 h and cooled to room temperature. The precipitate was collected by filtration to give title compound as yellow solid (Yield: 4.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07495007B2 |
|---|
| Source dataset | uspto-grants-2009_02 |
|---|
| ORD ID | ord-4d80cdbda84f4f29b1db794d30d6a07e |
|---|
| Source note | uspto-grants-2009_02 |
|---|
