HCID 68958299, compound → HCID 57566160, compound

Participants

Reaction Steps

The chiral (2′R,3R,4′S)-1′-(aminocarbonyl-methyl)-6-bromo-4′-(3-chlorophenyl)-2′-isopropenyl-2,3-dihydro-2,6′-dioxospiro[indole-3,3′-piperidine]-1-methoxyethyl trimethylsilane (27 mg, 0.043 mmol) was dissolved in a solution of trifluoroacetic acid (2 mL) in dichloromethane (5 mL). The reaction mixture was stirred at room temperature for 0.5 h, then concentrated. The residue was dissolved in a solution of methanol (3 mL) and N,N′-diisopropylethylamine (1 mL). The reaction tube was then placed into the cavity of a focused monomode microwave reactor and the contents of the flask were irradiated at 120° C. for 30 min. The reaction mixture was concentrated and the residue was purified by Prep-HPLC to give title compound (20 mg, 93%) m/z (M+H)+: 502

Provenance & Evidence