Aluminium lithium hydride → HCID 76568180, compound

Participants

Reaction Steps

To a mixture of LiAlH4 (2.5 mg, 0.066 mmol) in diethyl ether (1 mL) was added racemic (2′R,3R,4′S)-2′-[5-bromo-2-(1-ethoxycarbonyl-1-methyl-ethoxy)-phenyl]-6-chloro-4′-(3-chlorophenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione (10 mg, 0.016 mmol). The mixture was stirred at room temperature for 10 min, quenched with MeOH, purified by Prep-HPLC to give product (3.7 mg, 38%). (M+H)+: 603

Provenance & Evidence