Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 6-Chloro-1,3-dihydroindol-2-one | HCID 736344 | — |
| Reactant | HCID 57565924 | HCID 57565924 | — |
| Reactant | HCID 57566238 | HCID 57566238 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 68956475 | HCID 68956475 | — |
Reaction Steps
To the mixture of 6-chlorooxindole (10 g, 60 mmol) and 1-(4-chloro-2-formyl-phenoxy)-cyclobutanecarboxylic acid methyl ester (18 g, 64 mmol) in methanol (100 mL) was added pyrrolidine (4.5 g, 63 mmol) dropwise. The mixture was then heated at 70° C. for 1 h. After cooled to room temperature, the mixture was filtered and the precipitate was collected, dried to give a mixture of E/Z 1-[4-Chloro-2-(6-chloro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-phenoxy]-cyclobutanecarboxylic acid methyl ester (6 g, 24%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07495007B2 |
|---|
| Source dataset | uspto-grants-2009_02 |
|---|
| ORD ID | ord-2f1f62081ac3492384d3f3c0cc6663aa |
|---|
| Source note | uspto-grants-2009_02 |
|---|
