Water → HCID 76568098, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of racemic (2′R,3R,4′S)-6-chloro-4′-[5-chloro-2-(2-methoxycarbonyl-2-methyl-propoxy)-phenyl]-2′-isopropenylspiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione (20 mg), NaOH (80 mg), H2O (5 mL) and MeOH (1 mL) was heated at 80° C. for 2 h. Then the mixture was concentrated. The remaining aqueous solution was acidified by concentrated aqueous HCl solution (1.5 mL). The white precipitate was collected by filtration to give title compound (15 mg).

Provenance & Evidence