HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-Butylamine → 2-[4-(3-Acetoxy-1-butenyl)phenyl]-5-ethoxypyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-Butylamine | HCID 6385 | — |
| Reactant | 1-Methylallyl acetate | HCID 138821 | — |
| Reactant | 2-(4-Bromophenyl)-5-ethoxypyrimidine | HCID 19017116 | — |
| Catalyst | Triphenylphosphine | HCID 11776 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 2-[4-(3-Acetoxy-1-butenyl)phenyl]-5-ethoxypyrimidine | HCID 53899234 | 67% |
Reaction Steps
12 g of 2-(4-bromophenyl)-5-(ethoxy)pyrimidine, 12 g of 2-acetoxy-3-butene, 10 g of N-tert.butylamine, 20 ml of N-methylpyrrolidone, 0.12 g of palladium(II) acetate and 0.3 g of triphenylphosphine were reacted in analogous manner to Example 1(d) to give 9 g of 2-[4-(3-acetoxy-1-butenyl)phenyl]-5-ethoxypyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05326497 |
| Source dataset | uspto-grants-1994_07 |
| ORD ID | ord-866b7a68b8b7492bb86b9098ba59ce46 |
| Source note | uspto-grants-1994_07 |