HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Penten-1-OL → 5-Trimethylsilyloxy-2-(4-[5-hydroxy-1-pentenyl]phenyl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Penten-1-OL | HCID 13181 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 5-Trimethylsilyloxy-2-(4-bromophenyl)pyridine | HCID 19017102 | — |
| Catalyst | Triphenylphosphine | HCID 11776 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 5-Trimethylsilyloxy-2-(4-[5-hydroxy-1-pentenyl]phenyl)pyridine | HCID 54318196 | 88.6% |
Reaction Steps
6.0 g of 5-trimethylsilyloxy-2-(4-bromophenyl)pyridine, 2.5 g of 4-penten-1-ol, 4 g of sodium bicarbonate solution, 20 ml of N-methylpyrrolidone, 0.03 g of palladium(II) acetate and 0.11 g of triphenylphosphine were reacted in an analogous manner to Example 1(b) to give 5.4 g of 5-trimethylsilyloxy-2-(4-[5-hydroxy-1-pentenyl]phenyl)pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05326497 |
| Source dataset | uspto-grants-1994_07 |
| ORD ID | ord-3a00e3a2732e434ea8cf206169ca0e65 |
| Source note | uspto-grants-1994_07 |