HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-Butylamine → 2-[4-(3-Acetoxy-1-butenyl)phenyl]-5-trimethylsilyloxy-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-Butylamine | HCID 6385 | — |
| Reactant | 1-Methylallyl acetate | HCID 138821 | — |
| Reactant | 5-Trimethylsilyloxy-2-(4-bromophenyl)pyridine | HCID 19017102 | — |
| Catalyst | Triphenylphosphine | HCID 11776 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 2-[4-(3-Acetoxy-1-butenyl)phenyl]-5-trimethylsilyloxy-pyridine | HCID 54198349 | 74.7% |
Reaction Steps
17 g of 5-trimethylsilyloxy-2-(4-bromophenyl)pyridine, 12 g of 2-acetoxy-3-butene, 10 g of N-tert.-butylamine, 20 ml of N-methylpyrrolidone, 0.12 g of palladium(II) acetate and 0.3 g of triphenylphosphine are reacted in an analogous manner to Example 1(d) to give 14 g of 2-[4-(3-acetoxy-1-butenyl)-phenyl]-5-trimethylsilyloxy-pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05326497 |
| Source dataset | uspto-grants-1994_07 |
| ORD ID | ord-50e66bb5ea6c4ff5976320821ca4e934 |
| Source note | uspto-grants-1994_07 |