3-Methyl-DL-aspartic acid → N-benzyloxycarbonyl-3-methyl-D,L-aspartic acid

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Reaction Steps

Using a similar method to above 3-methyl-D,L-aspartic acid (10.0 g, 67 mmol), benzyl chloroformate (12 ml, 100 mmol) in 50% NaOH (16.7 g, 208 mmol ) in water (125 ml ) yielded N-benzyloxycarbonyl-3-methyl-D,L-aspartic acid 19.0 g as a low melting solid. 1H NMR (90 MHz, CDCl3 /d6DMSO): δ 1.1 (3,d), 2.9 (1,dt), 4.4 (1,m), 4.95 (2,s) 5.9 (1,bd) 7.2 (5,6) 7.9 (1,bs) .

Provenance & Evidence