Toluene → Ethanol ethylacetate

Participants

Reaction Conditions

Reaction Steps

2-Amino-4,5-dimethoxyacetophanone oxime (1.0 g, 4.76 mmol) was suspended in 35 ml toluene, and cyclopentanone (0.42 ml, 4.76 mmol) was added, followed by 10 mg of p- toluenesulfonic acid. The mixture was stirred at 55° C. for 24 hours. The resultant solid was collected by filtration and recrystallized from ethyl acetate-ethanol (39% yield). m.p. 225°-227 C.

Provenance & Evidence