Ammonium Chloride → 2-(4-(5-(Trifluoromethyl)-2-pyridinyloxy)phenyl)ethanol

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Reaction Steps

The (4-(5-(trifluoromethyl)-2-pyridinyloxy)phenyl)acetic acid ethyl ester (15.6 g, 48 mmol) was then added to a slurry of lithium aluminum hydride (2.3 g, 60 mmol) in ethyl ether (500 mL). The mixture was stirred overnight at room temperature. Then a saturated solution of ammonium chloride in water was added, and the title product, an oil, was separated from remaining solids by filtration. Yield 11 g.

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