反应详情

A mixture of 4-chloro-8-fluoroquinazoline (1.82 g, 0.01 mol), 2-(4-(5-trifluoromethyl-2-pyridinyloxy)-phenyl)ethylamine (2.82 g, 0.01 mol), triethylamine (1.1 g, 0.011 mol) and ethanol (50 mL) was heated under reflux for three hours and allowed to cool. Solvent was evaporated under reduced pressure, and the residue dissolved in dichloromethane. This was washed with 0.5M sodium hydroxide solution and water, and dried over anhydrous sodium sulphate. Evaporation of the solvent under reduced pressure and recrystallization from ethyl acetate:hexane gave 2.5 g of product. MP 152° C.

1. temperaturewas heated
2. temperatureunder reflux for three hours
3. temperatureto cool
4. customSolvent was evaporated under reduced pressure
5. dissolutionthe residue dissolved in dichloromethane
6. washThis was washed with 0.5M sodium hydroxide solution and water
7. dry with materialdried over anhydrous sodium sulphate
8. customEvaporation of the solvent
9. customunder reduced pressure and recrystallization from ethyl acetate