Allyl bromide → HCID 19017692, compound

HRID 1728349Notes

Reaction equation

[NH2:1][C:2]1[S:3][C:4]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][N:6]=1.[CH2:11](Br)[CH:12]=[CH2:13]>>[CH2:11]([NH:1][C:2]1[S:3][C:4]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][N:6]=1)[CH2:12][CH3:13]

Participants

Reactant 2

HCID 7841Allyl bromide

HCID 238005Methyl 2-aminothiazole-5-carboxylate

Product 1

HCID 19017692HCID 19017692, compound

Procedure

Methyl 2-aminothiazole-5-carboxylate, prepared by the procedure described in U.S. Pat. No. 4,001,421, is reacted with allyl bromide using the conditions described in Example 15A. This product is then hydrogenated using the procedure described in Example 15B to give methyl 2-propylaminothiazole-5-carboxylate.

Sources & evidence

ORD record: ord-718678423f05450aacc927cf2e89d0a8
Source dataset: uspto-grants-1994_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05326776

Reaction notes

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