HCID 18653518, compound → HCID 18653516, compound

Participants

Reaction Steps

8.8 g of 2-(R)-[[3-methyl-1-(S)-[(benzylamino)carbonyl]butyl]amino]-4-[((1,1-dimethylethyl)dimethylsilyl)oxy]-butanoic acid-1,1-dimethylethyl ester, prepared as in Example M, in 300 mL acetic acid was stirred for 24 h at 45° C. and the solvent was removed by evaporation. The residue was dissolved in 300 mL ethyl acetate, washed with 3×100 mL sodium bicarbonate, dried (MgSO4), filtered, and the solvents were removed by evaporation. The residue was purified by silica chromatography using methylene chloride:acetone (2:1) as eluent to give the title compound; 5.9 g.

Provenance & Evidence