HCID 18653519, compound → HCID 18653517, compound

Participants

Reaction Conditions

Reaction Steps

1.18 g of 2-(R)-[[3-methyl-1-(S)-[((pyridin-3-yl-methyl)amino)carbonyl]butyl]amino]-4-[((1,1-dimethylethyl)dimethylsilyl)oxy]-butanoic acid-1,1-dimethylethyl ester, prepared as in Example O, was added to 48 mL of acetic acid:water (9:1) and the mixture was heated to 45° C. and stirred 16 h. The solvents were removed by evaporation and the residue was dissolved in ethyl acetate, washed with saturated sodium bicarbonate, dried (MgSO4). The solvent was removed by evaporation and the residue was purified by silica chromatography using acetone:methylene chloride (1:1) as eluents to give the title compound; 0.513 g.

Provenance & Evidence