Dicyclohexylcarbodiimide → HCID 178445941, compound

Participants

Reaction Steps

50 mg of N-[(R)-1-[(1,1-dimethylethoxy)carbonyl]-3-(1,3-dihydro-1,3-dioxo-2H-benz[f]isoindol-2-yl)propyl]-L-leucine, prepared as in Example L, was added to of 40 mg N-hydroxysuccinamide in 5 mL DMF. 150 mg of dicyclohexylcarbodiimide was added and the mixture was stirred for 1 h. 43 mg of (1H-Tetrazol-5-ylmethyl)amine dihydrochloride was added followed by 1 mL triethylamine. The mixture was stirred for 18 h, filtered through celite, and the solvents removed by evaporation. The resulting residue was purified by reverse phase H.P.L.C. to give the title compound as a white solid; 18 mg.

Provenance & Evidence