Dimethylformamide → HCID 18653525, compound

Participants

Reaction Conditions

Reaction Steps

100 mg of N-[(R)-1-[(1,1-dimethylethoxy)carbonyl]-3-(1,3-dihydro-1,3-dioxo-2H-benz[f]isoindol-2-yl)propyl]-L-leucine, prepared as in Example L, was added to 2 mL DMF. 39.2 mg of hydroxybenzotriazol.H2O was added to the mixture, followed by 28.2 mL of N-methyl-4-morpholine and 38.3 mg of (2-methyl-2H-tetrazo-5-ylmethyl)amine The mixture was cooled to 0° C. and 52.8 mg of dicyclohexylcarbodiimide was added. The mixture was allowed to warm to 23° C. and was stirred for 24 h. The solvents were removed by evaporation and the resultant residue was diluted with ethyl acetate. The mixture was extracted with a saturated solution of sodium bicarbonate and the organic layer was separated, dried (MgSO4), and filtered. The solvent was removed by evaporation to afford the title compound; 120 mg.

Provenance & Evidence