Dicyclohexylcarbodiimide → HCID 10394325, compound

Participants

Reaction Steps

100 mg of N-[(R)-1-[(1,1-dimethylethoxy)carbonyl]-3-(1,3-dihydro-1,3-dioxo-2H-benz[f]isoindol-2-yl)propyl]-L-leucine, prepared as in Example L, was added to 0.8 mL DMF. 39 mg of hydroxybenzotriazol.H2O was added to the mixture followed by 57 mg of 4-aminoethylbenzenesulfonamide, 0.03 mL of N-methyl-4-morpholine, and 53 mg of dicyclohexylcarbodiimide. The mixture was stirred 72 h, and diluted with dichloromethane. The solvents were removed by evaporation and the resulting solid was purified by reverse phase H.P.L.C. The solvents were removed by lyopholization to give the title compound as a white solid; 104 mg.

Provenance & Evidence