Triphenylphosphine → HCID 18653508, compound

Participants

Reaction Conditions

Reaction Steps

325 mg of 2-(R)-[1-(S)-(benzylamino)carbonyl-3-methyl-butylamino]-4-hydroxy-butanoic acid-1,1-dimethylethyl ester, prepared as described for Example N, was added to 10 mL DMF, followed by 226 mg 5-bromo-1,3-dihydro-1,3-dioxo-2H-isoindole. 231 mg of triphenylphosphine was added and the mixture was cooled to 0° C. 0.14 mL diethyl azodicarboxylate was added and the mixture was warmed to RT with stirring for 16 h. The solvents were removed by evaporation and the resulting residue was purified by reverse phase H.P.L.C. to give the title compound; 53 mg.

Provenance & Evidence