Benzamidine → HCID 178516639, compound

HRID 1728400Notes

Reaction equation

HRID 1728400 reaction equation
[C:1]([NH2:9])(=[NH:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:10](OC)(=[O:16])[CH2:11][C:12](OC)=[O:13]>CS(C)=O>[C:2]1([C:1]2[N:9]=[C:12]([OH:13])[CH:11]=[C:10]([OH:16])[N:8]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 2332BenzamidineHCID 7943Dimethyl malonate

Product 1

HCID 178516639HCID 178516639, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

A mixture of benzamidine (7.42 g) and dimethyl malonate (8.09 g) in dry dimethyl sulfoxide (7 mL) was allowed to stand at room temperature for 24 h. The precipitated product was collected and washed with water and ether to afford 2-Phenyl-4,6-dihydroxy-pyrimidine as a white solid.

Workup

  1. customThe precipitated product was collected
  2. washwashed with water and ether

Sources & evidence

ORD record
ord-5f114e19af464464ab19e9e7481a2d55
Source dataset
uspto-grants-1994_07
Patent number
US05326868

Reaction notes

Loading…