Imidazole → HCID 53673103, compound

Participants

Reaction Steps

Reaction of 3,4-epoxy-1-butene and imidazole 1.95 g (0.0286 moles) of imidazole and 2.0 g (0.0286 moles) of 3,4-epoxy-1-butene were dissolved in 25 ml of THF. 0.83 g of the polymer-bound palladium(0) catalyst of Example 2 was then added to the reaction mixture. The reaction mixture was stirred at room temperature for 24 hours. The catalyst was removed by filtration and the filtrate was concentrated at reduced pressure. The residue was distilled. The reaction Yielded about 95% 4-(1-imidazoYl)-2-buten-1-ol (1,4 adduct) and less than 5% 3-(1-imidazoyl)-1-buten-4-ol (1,2 adduct). The combined yield of products was 63%.

Provenance & Evidence