Triethyl phosphite → HCID 19018239, compound

HRID 1728446Notes

Reaction equation

HRID 1728446 reaction equation
[CH3:1][C:2]1([CH2:8][O:9][C:10]2[CH:17]=[CH:16][C:13]([CH2:14]Br)=[CH:12][CH:11]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[CH2:18]([O:20][P:21]([O:25]CC)[O:22][CH2:23][CH3:24])[CH3:19]>>[CH3:1][C:2]1([CH2:8][O:9][C:10]2[CH:17]=[CH:16][C:13]([CH2:14][P:21](=[O:25])([O:22][CH2:23][CH3:24])[O:20][CH2:18][CH3:19])=[CH:12][CH:11]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 31215Triethyl phosphiteHCID 19018243HCID 19018243, compound

Product 1

HCID 19018239HCID 19018239, compound

Conditions

Temperature
145 °C

Procedure

A mixture of the 4-[((1-methyl)cyclohexyl)methoxy]benzyl bromide and 1.7 g (10 mmol) of triethylphosphite was heated at 145° C. for 0.2 hour. The reaction was cooled to room temperature and flash chromatographed to give 1.3 g of product as an oil.

Workup

  1. temperatureThe reaction was cooled to room temperature
  2. customflash chromatographed

Sources & evidence

ORD record
ord-417fd8ccc6fe4ef18f58cb0352619798
Source dataset
uspto-grants-1994_07
Patent number
US05326905

Reaction notes

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