Ethyl chloroformate → HCID 53862733, compound

HRID 1728501Notes

Reaction equation

Cl[C:2]([O:4][CH2:5][CH3:6])=[O:3].[C:7]([C:9](=[CH:21][C:22]1[CH:27]=[CH:26][C:25]([OH:28])=[C:24]([O:29][C:30]([O:32][CH2:33][CH3:34])=[O:31])[CH:23]=1)[C:10]([O:12][CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:11])#[N:8]>>[C:7]([C:9](=[CH:21][C:22]1[CH:27]=[CH:26][C:25]([O:28][C:2]([O:4][CH2:5][CH3:6])=[O:3])=[C:24]([O:29][C:30]([O:32][CH2:33][CH3:34])=[O:31])[CH:23]=1)[C:10]([O:12][CH2:13][CH2:14][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)=[O:11])#[N:8]

Participants

Reactant 2

HCID 10928Ethyl chloroformate

HCID 54179388HCID 54179388, compound2×

Product 1

HCID 53862733HCID 53862733, compound

Procedure

Further, reduction of the amount of ethyl chloroformate to 1/2 in the above-described process selectively provided phenethyl 2-cyano-3-(3-ethoxycarbonyloxy-4-hydroxyphenyl)-2-propenoate (Compound 17).

Sources & evidence

ORD record: ord-32e16b12312f4717b0929f4455d219ef
Source dataset: uspto-grants-1994_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05326785

Reaction notes

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