Ethyl chloroformate → HCID 53632373, compound

Participants

Role	Name	HCID	Charge
Reactant	Ethyl chloroformate	HCID 10928	—
Reactant	HCID 6610363	HCID 6610363	—
Reactant	HCID 53903019	HCID 53903019	—
Reactant	HCID 53971961	HCID 53971961	—
Reactant	HCID 53989437	HCID 53989437	—
Reactant	HCID 54122616	HCID 54122616	—
Reactant	HCID 54176288	HCID 54176288	—
Reactant	HCID 54262434	HCID 54262434	—
Reactant	HCID 54358728	HCID 54358728	—
Reactant	HCID 54410201	HCID 54410201	—
Product	HCID 53632373	HCID 53632373	—

Reaction Steps

By using 2-pyridylethyl 2-cyano-3-(3,4-dihydroxyphenyl)-2-propenoate, 8-(imidazol-1-yl)-octanyl 2-cyano-3-(3,4-dihydroxyphenyl)-2-propenoate, 4-aminophenethyl 2-cyano-3-(3,4-dihydroxyphenyl)-2-propenoate, phenoxyethyl 2-cyano-3-(3,4-dihydroxyphenyl)-2-propenoate and cinnamyl 2-cyano-3-(3,4-dihydroxyphenyl)-2-propenoate instead of phenethyl 2-cyano-3-(3,4-dihydroxyphenyl)-2-propenoate and 2.0-2.2 equivalents of ethyl chloroformate as an alkyl chloroformate and reacting them in a similar manner to the process of Example 1, 2-pyridylethyl 2-cyano-3-(3,4-diethoxycarbonyloxyphenyl)-2-propenoate (Compound 24), 8-(imidazol-1-yl)-octanyl 2-cyano-3-(3-ethoxycarbonyloxy-4-hydroxyphenyl)-2-propenoate (Compound 25), 4-aminophenethyl 2-cyano-3-(3,4-diethoxycarbonyloxyphenyl)-2-propenoate (Compound 26), phenoxyethyl 2-cyano-3-(3,4-diethoxycarbonyloxyphenyl)-2-propenoate (Compound 27) and cinnamyl 2-cyano-3-(3,4-diethoxycarbonyloxyphenyl)-2-propenoate (Compound 28) were obtained, respectively.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05326785
Source dataset	uspto-grants-1994_07
ORD ID	ord-33f44a91b0ce45eaa25ccf1acd118ba1
Source note	uspto-grants-1994_07