p-Toluenesulfonic acid → HCID 54138557, compound

Participants

Reaction Steps

A solution of 3.2 g of 1-[4-(4-pentylphenyl)-phenyl]-2,3-difluoro-4(1-hydroxypropyl)-benzene and 0.3 g of p-toluenesulphonic acid in 70 ml of toluene is heated at reflux temperature for one hour, then cooled, washed with saturated sodium bicarbonate solution and dried over anhydrous magnesium sulphate. Evaporation of the solvent gives 1-[4-(4-pentylphenyl)phenyl]-2,3-difluoro-4-(1-propenyl)-benzene as a crude Z/E isomer mixture.

Provenance & Evidence