反应详情

26 ml of thionyl chloride was dropwise added to 8.9 g of 4-chloro-2-(4-methylphenyl)benzamide, and the mixture was heated under reflux for 2.5 hr. Excess thionyl chloride was distilled off as much as possible by making use of toluene. The residue was recrystallized from a mixed solvent of tetrahydrofuran-isopropyl ether-n-hexane to prepare 7.2 g of a product.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 2.5 hr
3. distillationExcess thionyl chloride was distilled off as much as possible
4. customThe residue was recrystallized from a mixed solvent of tetrahydrofuran-isopropyl ether-n-hexane
5. customto prepare 7.2 g of a product