HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-4-nitro-1H-indole → 1-methyl-1H-indol-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-4-nitro-1H-indole | HCID 13168067 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-methyl-1H-indol-4-amine | HCID 22170307 | 106% |
Reaction Steps
A mixture of the nitroindole (D9) (0.5 g; 2.8 mM) and 5% palladium on charcoal in ethanol (75 ml) was hydrogenated at 60 p.s.i. (4.14×105Pa) at room temperature for 2 h. Removal of the catalyst by filtration followed by evaporation of the solvent gave the title compound (0.44 g; 97%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05328922 |
| Source dataset | uspto-grants-1994_07 |
| ORD ID | ord-6215b06473fb40efbed4991a7a038cf8 |
| Source note | uspto-grants-1994_07 |