Dimethylamine → N,N-dimethyl-5-nitropyridin-2-amine

Participants

Reaction Steps

2-Chloro-5-nitropyridine (1.58 g, 10 mM) was treated with a 33% w/w solution of dimethylamine in methylated spirit (18 ml, 100 mM). An exothermic reaction ensued, with formation of a yellow solid. After 0.5 h the solid was filtered off. The filtrate was evaporated and the residue was combined with the yellow solid, and all material was dissolved in dichloromethane. This solution was washed with water and brine, dried and evaporated, to give the title compound (1.64 g; 98%), m.p. 146°-149° C.

Provenance & Evidence