5-Amino-2-chloropyridine → HCID 19016528, compound

HRID 1728608Notes

Reaction equation

HRID 1728608 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[CH:6]=[CH:5]2.[C:12](C1NC=CN=1)(C1NC=CN=1)=[O:13].[NH2:24][C:25]1[CH:26]=[CH:27][C:28]([Cl:31])=[N:29][CH:30]=1>>[ClH:31].[CH3:11][N:7]1[C:8]2[C:4](=[CH:3][C:2]([NH:1][C:12]([NH:24][C:25]3[CH:26]=[CH:27][C:28]([Cl:31])=[N:29][CH:30]=3)=[O:13])=[CH:10][CH:9]=2)[CH:5]=[CH:6]1

Participants

4

Reactant 3

HCID 793055-Amino-2-chloropyridineHCID 27695641-methyl-1H-indol-5-amineHCID 5250894Bis-(1H-imidazol-2-YL)-methanone

Product 1

HCID 19016528HCID 19016528, compoundYield 60%

Procedure

The title compound was prepared in 60% yield from 5-amino-1-methyl-1H-indole (D3), carbonyl diimidazole and 5-amino-2-chloropyridine, using a procedure similar to that described in Example 13. m.p. 212° C.

Sources & evidence

ORD record
ord-9e74e724201b4e1c802e47d0489f779f
Source dataset
uspto-grants-1994_07
Patent number
US05328922

Reaction notes

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