HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 131718542, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Sesamol | HCID 68289 | — |
| Reactant | HCID 19014393 | HCID 19014393 | — |
| Reactant | HCID 131718535 | HCID 131718535 | — |
| Solvent | 4-Methyl-2-Pentanol | HCID 7910 | — |
| Product | HCID 131718542 | HCID 131718542 | — |
Reaction Steps
3-benzenesulphonyloxymethyl-1-butyl-4-(4-dimethyl-aminophenyl)piperidine (16) (2 g) (prepared from compound (12), benzenesulphonyl chloride and triethylamine by known procedures) was treated with sesamol (0.73 g) and NaOH (0.21 g) in MIBC as described for the preparation of compound (1). Reflux for 2 h. The crude product was purified several times on a silica gel column using CH2Cl2 /CH3OH 9/1 as eluent. Yield 0.05 g of colorless crystals after precipitation as the hydrochloride. M.p. 211.5°-214° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05328917 |
| Source dataset | uspto-grants-1994_07 |
| ORD ID | ord-32bf5b6cc4b04858a090265110e015a7 |
| Source note | uspto-grants-1994_07 |