3-(Trifluoromethyl)phenol → HCID 131718543, compound

Participants

Reaction Steps

0.4 g of 1-butyl-3-chloromethyl-4-(4-dimethylaminophenyl) piperidine (18) in DMF (25 ml) (prepared from compound (12) by known procedures) was added to a 70° C. hot mixture of 3-trifluoromethylphenol (0.28 g) and NaH (0.09 g) in DMF (25 ml). Reaction time 2 h at 100° C. Evaporation with 3×100 ml toluene. The residue was extracted with NaOH (4N)-ether, the etheral layer separated and dried (MgSO4), purified on a silica gel column and precipitated with concentrated HCl from acetone. Yield 0.22 g of colorless crystals. M.p. 221°-223° C.

Provenance & Evidence