HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 9892443, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Benzene, 1-fluoro-4-(trifluoromethyl)- | HCID 67873 | — |
| Reactant | Tetrafluoro-m-phenylenediamine dihydrochloride | HCID 149026 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | HCID 70053150 | HCID 70053150 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 9892443 | HCID 9892443 | — |
Reaction Steps
The piperidine base was prepared as described above from (±)-trans-1-butyl-3-hydroxymethyl-4-(4-dimethylaminophenyl)piperidine and 4-fluorobenzotrifluoride in dimethyl formamide with potassium tert-butoxide. The dihydrochloride was precipitated from an acetone solution by addition of 2.2 equivalents of conc. hydrochloric acid. The filtrate was evaporated at reduced pressure and the residue redispensed in acetone giving in all about 90% of the dihydrochloride. M.p. 211°-215° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05328917 |
| Source dataset | uspto-grants-1994_07 |
| ORD ID | ord-92674c130a0b4e1ca1f5824f492ca230 |
| Source note | uspto-grants-1994_07 |