Water → HCID 54208557, compound

Participants

Reaction Steps

A solution of the product of Example 1 (2.0 g) was dissolved in ethanol/dichloromethane (5:1, 100 ml) and treated with sodium borohydride (0.156 g). The reaction was stirred for 1 hour and then poured into water (500 ml), extracted with ethyl acetate, dried (MgSO4), filtered, and evaporated to yield an oil which was purified by chromatography on silica using ethyl acetate/petroleum ether (bp 60°-80° C.) to yield the title compound isomer A as a pale yellow solid (0.25 g) mp=190°-191° C.; found: C, 56.19; H, 3.93; N, 2.91; C23H19F6NO2S.0.25H2O requires C, 56.15; H, 4.00; N, 2.85%.

Provenance & Evidence