HCID 53694173, compound → HCID 19016558, compound

Participants

Reaction Steps

2-Acetamido-1-(3-benzo[b]thienyl)-5-(3,5-bistrifluoromethylphenyl)-4-penten-3-one (2.0 g) was hydrogenated in tetrahydrofuran (100 ml) using 10% Pd/C (0.5 g) at 50 p.s.i. The product was purified by chromatography on silica using ethyl acetate/petroleum ether (bp 60°-80° C.)(1:1) to yield the title compound as a white solid (1.2 g), mp=83°-84° C.; found: C, 56.41; H, 3.81; N, 2.84; C23H19F6NO2S requires C, 56.67; H, 3.93; N, 2.87%.

Provenance & Evidence