反应详情

A mixture of 1.0 g of product from Example 4 and 7.33 ml of methyl iodide is heated, in a dark sealed tube, at 100°-120° C. for 22 hours. The cooled reaction mixture is concentrated in vacuo and recrystallized 2 times from methyl alcohol to give 1.15 g of the desired product as light yellow microneedles.

1. temperatureis heated, in a dark sealed tube, at 100°-120° C. for 22 hours
2. customThe cooled reaction mixture
3. concentrationis concentrated in vacuo
4. customrecrystallized 2 times from methyl alcohol