HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 3-(Acetamidomethyl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 3-Pyridinemethanamine | HCID 31018 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 3-(Acetamidomethyl)pyridine | HCID 2735225 | — |
Reaction Steps
The title compound is prepared by the procedure of Example 12 using 50 g of 3-(aminomethyl)pyridine, 50.2 ml of acetic anhydride, 2.26 g of 4-dimethylaminopyridine and 150 ml of pyridine without heating at reflux. The residue is purified by column chromatography (silica gel: 20% methyl alcohol/ethyl acetate) to give 31.8 g of the desired product as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05328921 |
| Source dataset | uspto-grants-1994_07 |
| ORD ID | ord-7ff55c7015c14be7bf9cf0b265777411 |
| Source note | uspto-grants-1994_07 |