HuagongsheHuagongshe Chemistry Print Report · For research reference only
Myristyl bromide → [4-(Tetradecyloxy)phenyl]acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Myristyl bromide | HCID 8208 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Benzeneacetic acid, 4-hydroxy-, methyl ester | HCID 518900 | — |
| Catalyst | Potassium Iodide | HCID 4875 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | [4-(Tetradecyloxy)phenyl]acetic acid methyl ester | HCID 10316608 | 63.3% |
Reaction Steps
A mixture of 200 g of methyl 4-hydroxyphenylacetate, 350.4 g of 1-bromotetradecane, 207.9 g of potassium carbonate, 10 g of potassium iodide and 1.5 L of acetone is heated at reflux temperature for 24 hours. The reaction is cooled to room temperature, concentrated in vacuo and the residue is recrystallized from cold hexane to give 276.0 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05328921 |
| Source dataset | uspto-grants-1994_07 |
| ORD ID | ord-e88ce8d779c943d8b074dad71bd8cfa3 |
| Source note | uspto-grants-1994_07 |