Methyl iodide → 1-Methyl-2-[2-[[[4-(tetradecyloxy)phenyl]acetyl]amino]ethyl]pyridinium iodide

HRID 1728839Notes

Reaction equation

HRID 1728839 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][NH:9][C:10](=[O:33])[CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])=[CH:14][CH:13]=1.[CH3:34][I:35]>>[I-:35].[CH3:34][N+:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][NH:9][C:10](=[O:33])[CH2:11][C:12]1[CH:13]=[CH:14][C:15]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 10049546N-[2-(2-Pyridinyl)ethyl]-4-(tetradecyloxy)benzeneacetamide

Product 1

HCID 100313991-Methyl-2-[2-[[[4-(tetradecyloxy)phenyl]acetyl]amino]ethyl]pyridinium iodideYield 83%

Procedure

The title compound is prepared by the procedure of Example 28 using 1.0 g of product from Example 56 and 15.68 g of methyl iodide. The residue is recrystallized from methyl alcohol to give 1.09 g of the desired product as yellow crystals.

Workup

  1. customThe residue is recrystallized from methyl alcohol

Sources & evidence

ORD record
ord-51303bcebd084fb291ade497047c198a
Source dataset
uspto-grants-1994_07
Patent number
US05328921

Reaction notes

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