HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → N-(2-Pyridinylmethyl)-N-[[4-(tetradecyloxy)phenyl]methyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | N-(pyridin-2-ylmethyl)acetamide | HCID 5084090 | — |
| Reactant | 1-(Bromomethyl)-4-(tetradecyloxy)benzene | HCID 10022840 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(2-Pyridinylmethyl)-N-[[4-(tetradecyloxy)phenyl]methyl]acetamide | HCID 10004023 | 84.9% |
Reaction Steps
The title compound is prepared by the procedure of Example 27 using 9.4 g of product from Example 20, 3.87 g of product from Example 12, 1.24 g of 50% sodium hydride and 130 ml of dry tetrahydrofuran. The reaction is stirred at room temperature for 31/2 hours. The residue is purified by column chromatography (silica gel: 60-100% ethyl acetate/hexane) to give 9.42 g of the desired product as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05328921 |
| Source dataset | uspto-grants-1994_07 |
| ORD ID | ord-f098ba53838f4414a292d20c76fbf63c |
| Source note | uspto-grants-1994_07 |