反应详情

The title compound is prepared by the procedure of Example 27 using 2.55 g of product from Example 20, 0.999 g of product from Example 15, 0.319 g of washed 50% sodium hydride and 30 ml of tetrahydrofuran. The reaction is stirred at room temperature for hours, heated at reflux temperature for 24 hours; followed by stirring at room temperature for an additional 48 hours. The residue is purified by column chromatography (silica gel: 5% methyl alcohol/ethyl acetate) to give 0.862 g of the desired product. The spectral data indicates the presence of 2 rotomers.

1. temperatureheated
2. temperatureat reflux temperature for 24 hours
3. stirringby stirring at room temperature for an additional 48 hours
4. customThe residue is purified by column chromatography (silica gel: 5% methyl alcohol/ethyl acetate)