Methyl iodide → HCID 10326368, compound

HRID 1728896Notes

Reaction equation

HRID 1728896 reaction equation
[C:1]([N:4]([CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=1)[C:5](=[O:27])[C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[C:8]([C:23]([CH3:26])([CH3:25])[CH3:24])[CH:7]=1)(=[O:3])[CH3:2].[CH3:35][I:36]>>[I-:36].[C:1]([N:4]([CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][N+:30]=1[CH3:35])[C:5](=[O:27])[C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[C:8]([C:23]([CH3:24])([CH3:25])[CH3:26])[CH:7]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 10367290N-Acetyl-4-(decyloxy)-3-(1,1-dimethylethyl)-N-(2-pyridinylmethyl)benzamide

Product 1

HCID 10326368HCID 10326368, compoundYield 91.4%

Procedure

A mixture of 1.56 g of product from Example 133 and 23.68 g of methyl iodide is heated in a sealed tube, in the dark, at 105° C. for 18 hours. The reaction is concentrated in vacuo to give 1.86 g of the desired product as light yellow crystals.

Workup

  1. temperatureis heated in a sealed tube
  2. concentrationThe reaction is concentrated in vacuo

Sources & evidence

ORD record
ord-1b50bcd0fecb4164916e48e847ba82b2
Source dataset
uspto-grants-1994_07
Patent number
US05328921

Reaction notes

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