Acetic Acid → HCID 19016771, compound

Participants

Reaction Steps

A solution of diazomethane (1.5 g, 35.7 mmol) in ether (100 ml) was slowly added at 0° C. with stirring to a suspension of the above ester (18.59 mmol) in ether (100 mL). After the addition was completed, the solution was stirred at room temperature overnight. Excess diazomethane was decomposed by the slow and careful addition of dilute acetic acid and the mixture was concentrated in vacuo. Water (50 mL) was added and the mixture was thoroughly extracted with dichloromethane. The organic phase was washed with water, saturated sodium bicarbonate and again with water. The solution was dried and the solvent was removed in vacuo to give dimethyl 1-methyl-2-benzyl-4,5-imidazole dicarboxylate.

Provenance & Evidence